Abstract—Prevalence of Autoimmune diseases (AD) are high in developed countries and low in developing countries. Wall of worm were associated with lower level of allergy and support the hygiene hypothesis (HyHy). Long term use of Interferon as drug for AD and synthetic vaccine made by epitope mapping are global economic burden. Adolescence from developed countries traveling to Ghana forwarding AD-HyHy. Fecal microbiota transplantation (FMT) for fighting AD have been developed in hygiene countries such as UK, Japan and Korea, meanwhile the aims of this study are reveal an added value to Sade village ‘FMT culture’ and Bau Nyale/Mandalika Princess festival for Nature Vaccination on AD. These local nature vaccination needs to be known by policy maker and political doer and could be a translational-medicine education topic to lessen AD economic global burden. Method: Systematic-review and Bayesian network analysis. EBSCO host search engine were used. Result: Description of 9 Publications of meta-analysis are chosen. Conclusions: The increasing of immunity in developing countries and decreasing in clean habit educated family is based on hygiene hypothesis, could be answered by local life-style and festival. These added value for local tour package has been supported by affimers and aptamers contemporary technology based on bacteria and worm epitope mapping.
Keywords—hygiene hypothesis-autoimmune diseases, bacteria and worm cell wall, aptamers, epitope mapping, Fecal Microbiota Transplantation (FMT).
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