Abstract— Hypoxic ischemic encephalopathy (HIE) is due to failure to initiate and sustain breathing immediately after delivery which may leads to increase mortality and morbidity in these neonates. This may cause severe and permanent neuropsychological sequelae, including mental retardation, visual motor or visual perceptive dysfunction, increased hyperactivity, cerebral palsy and epilepsy. The brain damage may occur due to release of free radicals in HIE. So this case control study was conducted on 50 neonates with HIE and 25 healthy neonates with the aim to compare the status of oxidants and antioxidants in these both groups. It was observed that Malonyldialdehyde (MDA) was found with significantly increased in study group than control group i.e. 12.26±4.1 nmol/ml in study and 2.10±0.10 nmol/ml in control group. Among antioxidants, Catalase (30.42± 7.7 v/s 14.59± 4.7) and SOD (2.59± 0.4 v/s 1.54± 0.3) were found significantly increased whereas Vit E (1.36± 0.3 v/s 2.73± 0.6) was found significantly decreased in neonates with HIE than controls.
Keywords: Hypoxic ischemic encephalopathy (HIE), Malonyldialdehyde (MDA), Superoxide dismutase (SOD), Catalase and Vitamin E.
AD Publications is a rapidly growing academic publisher in the fields of Engineering, Medical-Health, Environmental Science and Agriculture Research. AD Publications is a registered organization broad-based open access and publishes most exciting researches with respect to the subjects of our journals. The Journals is being indexed and abstracted by all major global current awareness and alerting services.
The organization aims at undertaking, co- coordinating and promoting research and development. It provides professional and academic guidance in the field of basic education, Higher Education as well in the Technical Education. Our Aims is to Promote and support, High Quality basic, Scientific Research and development in fields of Engineering, Medical-Health, Environmental Science and Agriculture Research and to Generate Public awareness, provide advice to scholar’s researchers and communicate research outcomes.