Effect of Subcutaneous Administration of Teriparatide in Postmenopausal Osteoporosis

Abstract Postmenopausal osteoporosis is a serious health problem in Indian women as it increases chances of both vertebral and non-vertebral fractures. Currently standard treatment guidelines do not offer any effective prevention of osteoporosis. Teriparatide, in various international studies has been found as an effective treatment option for prevention of postmenopausal osteoporosis. However, there is very limited of data of Indian postmenopausal women. Therefore, present study is an attempt to observe the treatment effect of teriparatide for prevention of postmenopausal osteoporosis.

Objective: To observe the treatment effect of teriparatide in patients suffering from postmenopausal osteoporosis in terms of bone mineral density.

Methods: This randomized control study was done in 62 randomly selected patients with postmenopausal osteoporosis at SMS Hospital, Jaipur. After administering teriparatide (20 mcg daily), we measured lumbar spine, total hip and distal radius BMD at 6 and 12 months.

Results: At 6 months, lumbar spine BMD increased more in teriparatide group (0.74±1.43, P=0.007) than in control group (0±0.32, P=0.007) and at the end of 12 months also, lumbar spine BMD increased more in teriparatide group (0.8±0.43) than in control group (-0.03±0.41). Similarly, at 6 months, total hip BMD increased more in teriparatide group (0.36±0.45, P˂0.001) than in control group (-0.08±0.22, P˂0.001) and at the end of 12 months, total hip BMD increased more in teriparatide (0.59±0.45) than in control group (-0.1±0.36). ). At 6 months, distal radius BMD increased more in teriparatide group (0.44±0.74, P=0.004) compared to control group (0.00±0.37, P=0.004) and at 12 months, distal radius BMD increased more in teriparatide group (0.77±0.68) compared to control group (-0.04±0.43).

Conclusions: Teriparatide is an effective agent to treat postmenopausal osteoporosis and it is more effective at lumbar spine than at hip and radius. To conclude further treatment is needed as sequential therapy because on stopping treatment BMD again start receding over the period.

Keywords— Teriparatide, Postmenopausal women, Bone mineral density, Osteoporosis.

Click here to Download Full Paper

Medical Journal: Effect of Subcutaneous Administration of Teriparatide in Postmenopausal Osteoporosis

AD Publications is a rapidly growing academic publisher in the fields of Engineering, Medical-Health, Environmental Science and Agriculture Research. AD Publications is a registered organization broad-based open access and publishes most exciting researches with respect to the subjects of our journals. The Journals is being indexed and abstracted by all major global current awareness and alerting services.
The organization aims at undertaking, co- coordinating and promoting research and development. It provides professional and academic guidance in the field of basic education, Higher Education as well in the Technical Education. Our Aims is to Promote and support, High Quality basic, Scientific Research and development in fields of Engineering, Medical-Health, Environmental Science and Agriculture Research and to Generate Public awareness, provide advice to scholar’s researchers and communicate research outcomes.

Some Important Links About Research Journal

Medical Journal
Pharmaceutical Journal

International Journal
Agriculture Journal
Environmental Journal
Engineering Journal

Translate »