IJOER: August 2020

Engineering Journal: published its volume-6, Issue-8, August 2020 with AD Publications

In-Wheel Motor Transmission System in Electric Vehicle

Abstract Electric vehicle is the alternative, efficient and eco friendly in the future automobile industry. In today’s world due to depreciation of the fossil fuels rapidly, engineers have found the other mode of vehicle movement.ie- moving the car or a vehicle by the mode of electric motor. The end of the engines powered by fossil fuels and entering to the new era of electric automobile by 2075 almost 95% of the fossil fuel content and production from the earth will get over. There are electric vehicles like Tesla automobile and some other companies like Mahindra etc have started production of electric vehicles and the vehicle is powered by AC Induction motor, BLDC motor etc by using shafts and cv axle for transmission of power generated. Here this research paper is about the implementation of in-wheel electric motor, construction, mechanism and working of alternative design of 3 phase ac induction 4 pole motor with figures and tables.

Keywords— electric motor, efficiency, transmission system, transmission.

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Design, Formulation Development and Evaluation of Matrix Tablet Containing Labetalol HCL

Abstract The objective of present work was to design and develop sustained release matrix tablets of anti-hypertensive drug Labetalol hydrochloride. Hydroxypropyl methyl cellulose K15, Sodium CMC, Xanthan gum and Tamarind seed polysaccharide used as a rate retarding polymer. Whereas Polyvinyl Pyrrolidone and Microcrystalline cellulose are used as granulating agent and diluent. The influence of variable concentration of polymers on the release rate of drug was investigated. The results of the present work point out that the rate of Labetalol hydrochloride release from polymers like Hydroxypropyl methyl cellulose K15, Sodium CMC, Xanthan gum and Tamarind seed polysaccharide are mainly controlled by the drug–polymer ratio. The prepared sustained release matrix tablets were evaluated for various parameters like hardness, friability, uniformity of weight, uniformity of drug content and in vitro drug release studies.

Keywords— Hydroxypropyl methyl cellulose K15, Sodium CMC, Xanthan gum and Tamarind seed polysaccharide, Sustained-release, Labetalol hydrochloride Formulation.

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Synthesis and Biological Evaluation of Quinazolinone Derivatives as Antibacterial and Anti-Inflammatory Agents

Abstract Some novel 6,8-diiodo-2-methyl-3-substituted-quinazolin-4(3H)-ones bearing sulfon- amide derivatives (4–11) were synthesized in good yields and evaluated for their possible antibacterial, anti-inflammatory activities and acute toxicity. The structures of the synthesized compounds were confirmed on the basis of their spectral data and elemental analysis. Their antibacterial activities were evaluated by the agar well diffusion method while their anti-inflammatory activities were evaluated by the carrageenan-induced hind paw edema test. All the tested compounds showed con- siderable antibacterial activities and high to moderate anti-inflammatory activities that last for 12 h compared to ibuprofen. All the tested compounds showed no toxic symptoms or mortality rates 24 h post-administration at tested anti-inflammatory doses. In addition, LD50 for all tested com- pounds was higher than that for ibuprofen implying their good safety margin. The obtained results showed that the most active compounds could be useful as a template for future design, modification and investigation to produce more active analogs.

Keywords— Quinazolinone derivatives, Antibacterial Agents, Anti-Inflammatory Agents, Compound Sturcture.

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