Abstract— The potential of Convalescent Plasma Therapy (CPT) as the last effort for immunocompromised COVID-19 patients are not controversial anymore, but the mechanism which supports the anti-ligand-binding and memory cell should be broadly known. While p53 mutation associated CD4 has not been ready, memory cells could not know the lymphocyte induced up-regulation in cytokine storm stage, made lymphopenia. Keyword setting of lymphopenia mechanism-COVID-19, searching in Science Direct and other search engines, is used in this Systematic Review PRISMA design.
Immunocompromised patients including obese and old age is included, also Lymphocytopenia – ARDS, Diabetes Type 1. Cardiac arrest, cardiac arrhythmia, hypertension alone was excluded. References (15) that supported lymphocytopenia mechanism-COVID-19 are selected. About 15 million and 4,593 participants of COVID-19 patients with only 1½ Systematic Review due to the mechanism of lymphocytopenia and off reaction with CPT are recorded.
Lymphocytopenia cause by cytokine storm in week-2 COVID-19, while in low CD4 (Th) in this cytokine storm COVID-19, could be stronger and faster in week-1st in the second infection on person with diabetes. CPT serum, is the only way to switch-off cytotoxic activity, and increase the lymphocyte again.
CPT switch-off cytotoxic activity on Human Leucocyte Antigen (HLA) binding ligand in immunocompromised patients.
Keywords— Cytotoxic activity; HLA ligand binding; Lymphocytopenia; Lymphopenia; COVID-19; critical ARDS.
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