Biophysical profile of a case of Peeling Skin Syndrome – A model for study of Stratum Corneum function

Dr. Siddhi Tiwari 1, Dr. Ridhima Lakhani 2, Dr. Mahesh Prajapat 3, Dr. Puneet Bhargava4$

AbstractPeeling skin syndrome (PSS) is a rare recessively inherited ichthyosiform genodermatoses characterized clinically by asymptomatic, localized or generalized, continuous exfoliation of the superficial layer of the skin. A 12-year-old male child was presented with history of asymptomatic peeling of skin from his neck, trunk, and proximal extremities, since the age of 6 years. Histologically, stratum corneum was separated from the underlying stratum granulosum. Clinical and histopathological picture corresponded to the non-inflammatory variant of peeling skin syndrome (type A). Biophysical profile, which includes skin hydration, transepidermal water loss, sebum content, skin pH, of this patient was assessed from 7 different sites using the Corneometer, Tewameter, Sebumeter, Skin-pH-meter. Derangement was observed in all the above parameters. Peeling skin syndrome serves as a model for studying the stratum corneum functions. This article gives a critical review of the structure and various barrier functions of stratum corneum.

Key words: Peeling skin syndrome (PSS), stratum corneum, Biophysical profile

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