Background: Grey zone or intermediate zone CGG repeat in Pre-mutation FMR1 gene become in high prevalence in tropical rainforest area.
Problem: Bipolar disorder and Major depressive disorder used epigenetic drugs inhibitor to ameliorating their mood as well anticancer agent, decitabine are broadly used. Meanwhile, basic knowledge remains largely unknown.
Objective: Demethylation effect in grey zone methylation instability has to be controlled whereas up till now are to be disturbing the social behavior activities.
Hypothesis: Demethylation drive through, from >34 to <26 CGG repeat has behavior abnormalities.
Method: Quasi-Systematic Review with Bayesian network analysis using Science Direct and Ebsco-host search engine.
Result: One PRISMA Systematic Review flowchart to got the references and one table of 16 references to answer the methylation and demethylation in global living related to decitabine are recorded.
Discussion: Decitabine effect in epigenetic memory in mammals and neuro developmental, cognitive, behavioral and physical changes in grey zone and carrier permutation FMR1 gene are scanned.
Conclusion: Demethylation to high as well low grey zone CGG count could be self monitor due to instable methylation.
Keywords: decitabine, hypomethylation, CGG repeat, tremor, cognitive, epigenetic instability.
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