Microwave-assisted Synthesis of Some N-alkylisatin-B-thiocarbohydrazones

Abstract The effectiveness of microwave-assisted preparation of N-alkylisatin-b-thiocarbohydrazones, where alkyl group is methyl and ethyl, was evaluated. The corresponding N-alkylisatin-b-thiocarbohydrazones were predominantly obtained by TCH and N-alkyl substituted isatin in molar ratio 3:1. Reactions of carbonyl-amine condensation were performed in water acidified to pH 1.5 as a solvent system. Reaction mixtures were exposed to microwave irradiation under 300W and pressure 200 psi, for a specified incubation period of 5-15 min. The yield of products obtained by microwave assisted reaction was similar to that had been obtained using conventional reflux method (about 70% to 80%), with reduction of time. The structures of synthesized N-alkylisatins and corresponding N-alkylisatin-b-thiocarbohydrazones were established on the basis of recorded spectral data from IR, GC-MS, 1H NMR and 13C NMR.

Keywords Microwave-assisted organic synthesis (MAOS), N-alkylisatin, N-alkylisatin-b-thiocarbohydrazone.

Click here to Download Full Paper

Engineering Journal: Microwave-assisted Synthesis of Some N-alkylisatin--thiocarbohydrazones

AD Publications is a rapidly growing academic publisher in the fields of Engineering, Medical-Health, Environmental Science and Agriculture Research. AD Publications is a registered organization broad-based open access and publishes most exciting researches with respect to the subjects of our journals. The Journals is being indexed and abstracted by all major global current awareness and alerting services.
The organization aims at undertaking, co- coordinating and promoting research and development. It provides professional and academic guidance in the field of basic education, Higher Education as well in the Technical Education. Our Aims is to Promote and support, High Quality basic, Scientific Research and development in fields of Engineering, Medical-Health, Environmental Science and Agriculture Research and to Generate Public awareness, provide advice to scholar’s researchers and communicate research outcomes.

Some Important Links About Research Journal
International Journal
Agriculture Journal
Medical Journal
Environmental Journal
Engineering Journal

Translate »