A new tool for inhalers’ use and adherence monitoring: the Amiko® validation trial

Abstract The lack of adherence to treatment and misuse of inhaled medication are hot topics in asthma and COPD management. Novel electronic monitoring devices are regarded as promising in assessing medication use. The aim of this study was the experimental performance evaluation of an electronic monitoring device (Amiko®) on Ellipta®  (GlaxoSmithKline), Spiromax®  (Teva Pharmaceutical Industries), and NEXThaler®  (Chiesi Farmaceutici). Amiko® introduces a clinically negligible inspiratory flow resistance when added to the tested DPI. It was able to detect the performed inhalation in more than 99% of cases providing also an estimate of the patient’s inspiratory effort with a limited gap across the different devices. All the loading manoeuvres were recorded correctly for each DPI, independently of the orientation of the device, resulting in an accuracy of 100.0%. Similarly, the tool was able to detect the device orientation during the performed inhalation with a mean absolute error inferior than 3.53° for the three DPIs. All the above reported results suggest that Amiko® technology will allow to identify, store and communicate relevant data for adherence improvement and misuse correction. Usability test, efficacy and effectiveness in improving respiratory disease management, need to be explored in clinical research setting and in real life.

Keywords inhaled device, loading, recording, orientation, inspiratory effort.

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A new tool for inhalers' use and adherence monitoring: the Amiko® validation trial

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