Abstract— Oligoguanidine with chain extension were synthesized by condensation and cross-linking polymerizations in an attempt to increase molecular weight and charge density of the anti microbial oligoguanidine. The reactions are procedure at 170 oC for 5h with ratio molar of HMDA: GHC = 1: 1.1, refined by vacuum filter at 60 oC. The Oligoguanidine OHMG.HCl synthesized has molecular weight equal 521 g/mol, chain structure and good water solubility. The comparison results of the antimicrobial activities of oligoguanidine with chloramine B indicated that MIC index of OHMG.HCl is 5ppm during MIC index of chloramine B is 50 ppm; MBC of OHMG.HCl is 12 minutes and MBC of chloramine B is 11 minutes; The SEM, TEM imagines exhibited clear biocide, low residue microorganism of OHMG.HCl. The LC-MS spectrum indicates the presence of haloacetic acid following the bactericidal action of chloramphen B, while OHGM.HCl is not available. This result confirms the environmental friendliness of oligoguanidine.
Keywords— Oligoguanidine, Oligohexamethylene guanidine hydrochloride, antimicrobial polymer.
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