Tear dysfunction syndrome: Microstructural findings in vivo

Abstract

Purpose: To evaluate the morphological changes of the Meibomian glands in patients with evaporative “dry eye” compared to normal subjects by in vivo laser scanning confocal microscopy (LSCM). To correlate these changes to the clinical observations and tear functions.

Methods: The study was based on trans-tarsal images of 30 normal and 30 diseased lids (patients with subjective complaints and objective symptoms of evaporative “dry eye”). Each participant was examined by in vivo LSCM (HRT3 Rostock corneal module). The results were compared to histological findings of normal or pathologically changed Meibomian glands.

Results: Patients with evaporative “dry eye” presented with destructive changes of the Meibomian glands as follows: occlusion of the lumen, impaired morphology of the acines, lack of normal structure and infiltration with inflammatory cells. Reported ocular surface and tear function abnormalities were correlated to the Meibomian glands dysfunction (MGD). In all cases the lid hygiene and anti-inflammatory treatment demonstrated tendency to restoration of the structure.

Cоnclusion: In vivo LSCM can effectively demonstrate the morphological changes of the Meibomian glands in patients with evaporative dry eye symptoms. This noninvasive technology is useful as a supplementary diagnostic tool for in vivo assessment of the histopathology of many ocular surface disorders and monitoring of the therapeutic effect in patients with MGD. Glandular acinar density and acinar unit diameter seemed to be promising new parameters of Meibomian glands in vivo confocal microscopy. The examination has the potential to change the evaporative dry eye treatment approach.

Keywords Dry Eye, in vivo Laser Confocal Microscopy, Meibomian glands

Click here to Download Full Paper

Anemia among Adolescent Girls and its socio-demographic Associates

AD Publications is a rapidly growing academic publisher in the fields of Engineering, Medical-Health, Environmental Science and Agriculture Research. AD Publications is a registered organization broad-based open access and publishes most exciting researches with respect to the subjects of our journals. The Journals is being indexed and abstracted by all major global current awareness and alerting services.
The organization aims at undertaking, co- coordinating and promoting research and development. It provides professional and academic guidance in the field of basic education, Higher Education as well in the Technical Education. Our Aims is to Promote and support, High Quality basic, Scientific Research and development in fields of Engineering, Medical-Health, Environmental Science and Agriculture Research and to Generate Public awareness, provide advice to scholar’s researchers and communicate research outcomes.

Some Important Links About Research Journal
International Journal
Agriculture Journal
Medical Journal
Environmental Journal
Engineering Journal

Translate »